Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM352085
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM352085
Synonyms:
2-(6-((4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-ylamino)methyl)-3-fluoropyridin-2-yl)-3-fluorobenzonitrile | US9802918, Example 17
Type:
Small organic molecule
Emp. Form.:
C24H24F2N6O
Mol. Mass.:
450.4838
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1C#N |r,wU:5.5,1.0,wD:7.8,(-1.33,2.69,;-2.67,1.92,;-2.67,.38,;-4,-.39,;-5.33,.38,;-5.33,1.92,;-6.67,2.69,;-4,2.69,;-4,4.23,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.23,;-4,-5,;-2.67,-4.23,;-2.67,-2.7,;-1.33,-1.92,;,-2.69,;1.33,-1.92,;2.67,-2.69,;4,-1.92,;4,-.38,;5.33,.39,;2.67,.38,;1.33,-.38,;2.67,1.92,;1.33,2.69,;,1.93,;1.33,4.23,;2.67,5,;4,4.23,;4.05,2.67,;5.38,1.9,;6.72,1.13,)|
Structure:
Search PDB for entries with ligand similarity: