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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352093
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352093
Synonyms:
2-(4-{6-[({4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenyl)-2-methylpropanenitrile | US9802918, Example 24
Type:
Small organic molecule
Emp. Form.:
C27H29F3N6O
Mol. Mass.:
510.554
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N |r,wU:7.8,wD:5.5,1.0,(.99,-.91,;2.32,-1.68,;2.32,-3.22,;3.66,-3.99,;4.99,-3.22,;4.99,-1.68,;6.33,-.91,;3.66,-.91,;3.66,.63,;3.66,-5.53,;4.99,-6.3,;4.99,-7.84,;3.66,-8.61,;2.32,-7.84,;2.32,-6.3,;.99,-5.53,;.99,-3.99,;-.34,-3.22,;-1.68,-3.99,;-3.01,-3.22,;-3.01,-1.68,;-4.34,-.91,;-1.68,-.91,;-.34,-1.68,;-1.68,.63,;-.34,1.4,;.99,.63,;-.34,2.94,;-1.68,3.71,;-3.01,2.94,;-3.01,1.4,;-4.34,.63,;-1.68,5.25,;-.14,5.25,;-3.22,5.25,;-1.68,6.79,;-1.68,8.33,)|
Structure:
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