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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352094
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352094
Synonyms:
2-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenyl)-2-methylpropanenitrile | US9802918, Example 24A
Type:
Small organic molecule
Emp. Form.:
C27H29F3N6
Mol. Mass.:
494.5546
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N |r,wD:3.3,1.0,(1.19,-.94,;2.52,-1.71,;3.85,-.94,;5.19,-1.71,;6.52,-.94,;5.19,-3.25,;3.85,-4.02,;2.52,-3.25,;3.85,-5.56,;5.19,-6.33,;5.19,-7.87,;3.85,-8.64,;2.52,-7.87,;2.52,-6.33,;1.19,-5.56,;1.19,-4.02,;-.15,-3.25,;-1.48,-4.02,;-2.82,-3.25,;-2.82,-1.71,;-4.15,-.94,;-1.48,-.94,;-.15,-1.71,;-1.48,.6,;-.15,1.37,;1.19,.6,;-.15,2.91,;-1.48,3.68,;-2.82,2.91,;-2.82,1.37,;-4.15,.6,;-1.48,5.22,;.06,5.22,;-3.02,5.22,;-1.48,6.76,;-1.48,8.3,)|
Structure:
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