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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM352168
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM352168
Synonyms:
1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenoxy)-2-methylpropan-2-ol | US9802918, Example 103
Type:
Small organic molecule
Emp. Form.:
C27H32F3N5O2
Mol. Mass.:
515.5705
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(OCC(C)(C)O)cc1F |r,wU:3.3,1.0,(-.67,,;-2,-.77,;-3.33,,;-4.67,-.77,;-6,,;-4.67,-2.31,;-3.33,-3.08,;-2,-2.31,;-3.33,-4.62,;-4.67,-5.39,;-4.67,-6.93,;-3.33,-7.7,;-2,-6.93,;-2,-5.39,;-.67,-4.62,;.67,-5.39,;2,-4.62,;3.33,-5.39,;4.67,-4.62,;4.67,-3.08,;6,-2.31,;3.33,-2.31,;2,-3.08,;3.33,-.77,;2,,;.67,-.77,;2,1.54,;3.33,2.31,;3.33,3.85,;2,4.62,;2,6.16,;.67,6.93,;2,7.7,;3.33,6.93,;4.67,1.54,;4.67,,;6,-.77,)|
Structure:
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