Reaction Details Report a problem with these data
Target
Phosphodiesterase
Ligand
BDBM355375
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
Ki
0.850±n/a nM
Citation
More Info.:
Target
Name:
Phosphodiesterase
Synonyms:
PDE2A3 | Phosphodiesterase A3 (PDE2A3)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
105547.91
Organism:
Macaca mulatta (Rhesus macaque)
Description:
n/a
Residue:
941
Sequence:
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
Inhibitor
Name:
BDBM355375
Synonyms:
N-{(1R)-1-[3-fluoro-4- (trifluoromethyl)phenyl]-2,2- dimethylpropyl}-2-(4- methoxybenzyl)-6-oxo-1,6- dihydropyrimidine-4-carboxamide | US9815796, Example 466
Type:
Small organic molecule
Emp. Form.:
C25H25F4N3O3
Mol. Mass.:
491.4779
SMILES:
COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)cc1 |r|