Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM355777
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
329±n/a nM
Citation
 Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM Azabenzimidazole compounds US Patent  US9815832 Publication Date 11/14/2017 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM355777
Synonyms:
3-(5-Chloro-2-methylphenyl)-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-2-carboxamide | US9815832, 54
Type:
Small organic molecule
Emp. Form.:
C17H15ClN4O
Mol. Mass.:
326.78
SMILES:
Cc1ccc(Cl)cc1-n1c(nc2cccnc12)C(=O)NC1CC1 |(-3.16,1.62,;-1.67,2.02,;-1.27,3.51,;.22,3.91,;1.31,2.82,;2.79,3.22,;.91,1.33,;-.58,.93,;-.98,-.56,;-.07,-1.8,;-.98,-3.05,;-2.44,-2.57,;-3.78,-3.34,;-5.11,-2.57,;-5.11,-1.03,;-3.78,-.26,;-2.44,-1.03,;1.47,-1.8,;2.24,-.47,;2.24,-3.14,;3.78,-3.14,;5.11,-3.91,;5.11,-2.37,)|
Structure:
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