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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242391
Substrate
n/a
Meas. Tech.
Pim-1 Kinase Inhibition Assay
Temperature
298.15±n/a K
IC50
58.0±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10047093 Publication Date 8/14/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242391
Synonyms:
US10047093, 8-72 | US10392392, Example 8-72 | US10875864, EX. 8-72 | US9416132, 8-72
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O
Mol. Mass.:
340.807
SMILES:
Clc1cccc(c1)-c1cnc2ccc(NC3CCC(=O)CC3)nn12
Structure:
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