Reaction Details Report a problem with these data
Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357486
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
7.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357486
Synonyms:
US10214519, Example 230 | US10214519, Example 356 | US10214519, Example 357
Type:
Small organic molecule
Emp. Form.:
C26H23F2N5O2
Mol. Mass.:
475.4899
SMILES:
CCCc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1ncco1 |(-6.8,-.65,;-5.31,-1.04,;-4.22,.04,;-2.73,-.35,;-2.18,-1.79,;-.64,-1.71,;.45,-2.8,;1.93,-2.4,;2.33,-.91,;1.24,.18,;-.24,-.22,;-1.53,.62,;-1.53,2.16,;-.2,2.93,;-.2,4.47,;-1.53,5.24,;-2.87,4.47,;-4.2,5.24,;-4.2,6.78,;-5.54,4.47,;-5.54,2.93,;-4.2,2.16,;-4.2,.62,;-2.87,2.93,;3.82,-.52,;4.91,-1.6,;6.4,-1.21,;6.8,.28,;5.71,1.37,;4.22,.97,;.05,-4.29,;1.02,-5.48,;.18,-6.78,;-1.31,-6.38,;-1.39,-4.84,)|
Structure:
Search PDB for entries with ligand similarity: