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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357494
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
4.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357494
Synonyms:
US10214519, Example 238
Type:
Small organic molecule
Emp. Form.:
C25H21ClFN5OS
Mol. Mass.:
493.984
SMILES:
Cc1csc(n1)-c1cc(cc2n(c(C)nc12)-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1 |(-3.03,-7.12,;-1.94,-6.03,;-.45,-6.43,;.39,-5.14,;-.58,-3.94,;-2.02,-4.49,;-.18,-2.45,;1.3,-2.06,;1.7,-.57,;.61,.52,;-.87,.12,;-2.16,.96,;-3.36,-.01,;-4.85,.39,;-2.81,-1.45,;-1.27,-1.37,;-2.16,2.5,;-.83,3.27,;-.83,4.81,;-2.16,5.58,;-3.5,4.81,;-4.83,5.58,;-4.83,7.12,;-6.17,4.81,;-6.17,3.27,;-4.83,2.5,;-4.83,.96,;-3.5,3.27,;3.19,-.17,;4.28,-1.26,;5.77,-.86,;6.17,.63,;5.08,1.72,;3.59,1.32,)|
Structure:
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