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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357529
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
4.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357529
Synonyms:
US10214519, Example 285
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2N6O
Mol. Mass.:
465.335
SMILES:
Clc1ncc([nH]1)-c1cc(cc2n(cnc12)-c1ccnc2c(Cl)cccc12)N1CCOCC1
Structure:
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