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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357609
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
6.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357609
Synonyms:
US10214519, Example 372 | US10214519, Example 373
Type:
Small organic molecule
Emp. Form.:
C24H19ClF2N6O
Mol. Mass.:
480.897
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2c(F)ccc(F)c12)N1CCOCC1)-c1cnc(Cl)[nH]1 |(-4.86,-.51,;-3.37,-.11,;-2.89,-1.57,;-1.35,-1.57,;-.32,-2.72,;1.18,-2.4,;1.66,-.93,;.63,.21,;-.88,-.11,;-2.12,.8,;-2.12,2.37,;-.79,3.14,;-.79,4.68,;-2.12,5.45,;-3.46,4.68,;-4.79,5.45,;-4.79,6.99,;-6.12,4.68,;-6.12,3.14,;-4.79,2.37,;-4.79,.83,;-3.46,3.14,;3.15,-.53,;4.24,-1.62,;5.72,-1.23,;6.12,.26,;5.03,1.35,;3.55,.95,;-.72,-4.21,;.18,-5.45,;-.72,-6.7,;-2.18,-6.22,;-3.52,-6.99,;-2.18,-4.68,)|
Structure:
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