Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM360608
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
4411±n/a nM
Citation
 Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US9828369 Publication Date 11/28/2017 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM360608
Synonyms:
1-(2,3-dichlorophenyl)-3-((5-(3- (morpholine-4- carbonyl)phenyl)isoquinolin-8- yl)methyl)urea | US9828369, Example 166
Type:
Small organic molecule
Emp. Form.:
C28H24Cl2N4O3
Mol. Mass.:
535.421
SMILES:
Clc1cccc(NC(=O)NCc2ccc(-c3cccc(c3)C(=O)N3CCOCC3)c3ccncc23)c1Cl
Structure:
Search PDB for entries with ligand similarity: