Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM362805
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
4.10±n/a nM
Citation
 Galley, G; Pflieger, P; Norcross, R; Cecere, G; Shen, H; Hu, Y Morpholin-pyridine derivatives US Patent  US9840501 Publication Date 12/12/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM362805
Synonyms:
2-Isopropyl-N-[6-[(2R)-morpholin-2-yl]-3-pyridyl]-5-(2,2,2-trifluoroethoxy)pyrazole-3-carboxamide | US9840501, Example 99
Type:
Small organic molecule
Emp. Form.:
C18H22F3N5O3
Mol. Mass.:
413.3942
SMILES:
CC(C)n1nc(OCC(F)(F)F)cc1C(=O)Nc1ccc(nc1)[C@H]1CNCCO1 |r|
Structure:
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