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Target
Ceramide glucosyltransferase
Ligand
BDBM367619
Substrate
n/a
Meas. Tech.
GCS Enzymatic Assay
IC50
55±n/a nM
Citation
 Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent  US10227312 Publication Date 3/12/2019 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM367619
Synonyms:
N-((1R,2R)-1-(4-cyclopropoxyphenyl)- 1-hydroxy-3-(pyrrolidin-1-yl)propan-2- yl)-7-(4-fluorophenyl)-1H- benzo[d][1,2]oxazine-4-carboxamide | US10227312, Example 4 | US10759769, Example 4
Type:
Small organic molecule
Emp. Form.:
C31H32FN3O4
Mol. Mass.:
529.6019
SMILES:
O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1=NOCc2cc(ccc12)-c1ccc(F)cc1)c1ccc(OC2CC2)cc1 |r,t:13|
Structure:
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