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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368668
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
3.00±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368668
Synonyms:
US10227350, Compound 85
Type:
Small organic molecule
Emp. Form.:
C26H17ClF2N8
Mol. Mass.:
514.917
SMILES:
Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(C4CC4)n(-c4ccnc5c(Cl)ccc(F)c45)c3c2)c1F |(6.53,-2.44,;5.44,-1.35,;5.84,.13,;4.75,1.22,;3.26,.82,;2.86,-.66,;1.37,-1.06,;.9,-2.53,;-.61,-2.85,;-1.01,-4.33,;-.1,-5.58,;-1.01,-6.83,;-2.47,-6.35,;-2.47,-4.81,;-1.64,-1.7,;-3.18,-1.7,;-3.65,-.24,;-5.19,-.24,;-6.53,.53,;-6.53,-1.01,;-2.41,.67,;-2.41,2.21,;-1.07,2.98,;-1.07,4.52,;-2.41,5.29,;-3.74,4.52,;-5.08,5.29,;-5.08,6.83,;-6.41,4.52,;-6.41,2.98,;-5.08,2.21,;-5.08,.67,;-3.74,2.98,;-1.16,-.24,;.34,.08,;3.95,-1.75,;3.55,-3.24,)|
Structure:
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