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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368681
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
7.00±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368681
Synonyms:
US10227350, Compound 96
Type:
Small organic molecule
Emp. Form.:
C27H19F3N8
Mol. Mass.:
512.4886
SMILES:
Nc1nccc(-c2cc(-c3nnc[nH]3)c3nc(CC4CC4)n(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F |(6.91,-2.44,;5.82,-1.35,;6.22,.13,;5.13,1.22,;3.65,.82,;3.25,-.66,;1.76,-1.06,;1.28,-2.53,;-.22,-2.85,;-.62,-4.33,;.28,-5.58,;-.62,-6.83,;-2.09,-6.35,;-2.09,-4.81,;-1.25,-1.7,;-2.79,-1.7,;-3.27,-.24,;-4.81,-.24,;-5.58,-1.57,;-6.91,-2.34,;-5.58,-3.11,;-2.02,.67,;-2.02,2.21,;-.69,2.98,;-.69,4.52,;-2.02,5.29,;-3.36,4.52,;-4.69,5.29,;-4.69,6.83,;-6.02,4.52,;-6.02,2.98,;-4.69,2.21,;-4.69,.67,;-3.36,2.98,;-.78,-.24,;.73,.08,;4.34,-1.75,;3.94,-3.24,)|
Structure:
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