Reaction Details Report a problem with these data
Target
Diacylglycerol kinase zeta
Ligand
BDBM615902
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
<10±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023 
Target
Name:
Diacylglycerol kinase zeta
Synonyms:
2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta
Type:
PROTEIN
Mol. Mass.:
124177.85
Organism:
Homo sapiens
Description:
ChEMBL_117547
Residue:
1117
Sequence:
METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
  
Inhibitor
Name:
BDBM615902
Synonyms:
US20230271954, Compound 201 | cis-8-((-4-((4-fluorophenyl)((trans-3- hydroxycyclobutyl)methyl)amino)cyclohexyl) (methyl)amino)-5-methyl-6-oxo-5,6-dihydro-1,5- naphthyridine-2,7-dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C29H31FN6O2
Mol. Mass.:
514.5938
SMILES:
CN(C1CC[C@@H](CC1)N(CC1C[C@H](O)C1)c1ccc(F)cc1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:5.8,wD:12.13,(-2.94,-3.47,;-2.94,-1.93,;-1.61,-1.15,;-.28,-1.93,;1.06,-1.15,;1.06,.38,;-.28,1.15,;-1.61,.38,;2.39,1.15,;3.72,.38,;5.06,1.15,;5.46,2.64,;6.94,2.24,;8.28,3.01,;6.55,.76,;2.39,2.69,;3.72,3.47,;3.72,5,;2.39,5.78,;2.39,7.31,;1.06,5,;1.06,3.47,;-4.28,-1.16,;-4.28,.38,;-2.94,1.15,;-1.61,1.92,;-5.61,1.15,;-5.61,2.69,;-6.94,.39,;-8.28,1.15,;-6.94,-1.15,;-8.28,-1.93,;-8.28,-3.47,;-6.94,-4.29,;-5.61,-3.47,;-5.61,-1.93,;-6.94,-5.83,;-6.94,-7.37,)|
Structure:
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