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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM255782
Substrate
n/a
Meas. Tech.
S1P Assay
EC50
200±n/a nM
Citation
 Gill, GS; Grobelny, DW S1P receptors modulators and their use thereof US Patent  US9707205 Publication Date 7/18/2017 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM255782
Synonyms:
1-((4′-(3-(3-(Trifluoromethyl)phenyl)but-2-enoyl)biphenyl-4-yl)methyl)azetidine-3-carboxylic acid | US9707205, 29
Type:
Small organic molecule
Emp. Form.:
C28H24F3NO3
Mol. Mass.:
479.4903
SMILES:
C\C(=C\C(=O)c1ccc(cc1)-c1ccc(CN2CC(C2)C(O)=O)cc1)c1cccc(c1)C(F)(F)F
Structure:
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