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Target
Cathepsin K
Ligand
BDBM150548
Substrate
n/a
Meas. Tech.
Inhibition of Human Cathepsin K
IC50
1700±n/a nM
Citation
 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C US Patent  US10238633 Publication Date 3/26/2019 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM150548
Synonyms:
US10238633, Example 222 | US8987249, 222 | US9713606, 222
Type:
Small organic molecule
Emp. Form.:
C24H24FN5O2S
Mol. Mass.:
465.543
SMILES:
CS(=O)(=NC#N)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r|
Structure:
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