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Target
D(2) dopamine receptor
Ligand
BDBM371889
Substrate
n/a
Meas. Tech.
3H]-Spiperone Binding Assay
Ki
191±n/a nM
Citation
 Cremonesi, S; Micheli, F; Semerano, T; Tarsi, L Dopamine D3 receptor antagonists US Patent  US10239870 Publication Date 3/26/2019 
Target
Name:
D(2) dopamine receptor
Synonyms:
D2(Short) | Dopamine D2 S receptor
Type:
n/a
Mol. Mass.:
47370.77
Organism:
Homo sapiens (Human)
Description:
P14416-2
Residue:
414
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM371889
Synonyms:
US10239870, Example 108
Type:
Small organic molecule
Emp. Form.:
C25H34F3N5S
Mol. Mass.:
493.631
SMILES:
Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3)C(F)(F)F)C2)nnc1C1CCC(N)CC1 |r,wU:10.10,(2.89,-3.03,;3.69,-1.72,;3.1,-.29,;1.62,.1,;1.22,1.59,;-.27,1.99,;-.67,3.48,;-2.16,3.88,;-3.13,5.07,;-4.56,4.52,;-4.48,2.98,;-5.82,3.75,;-5.82,2.21,;-6.59,.88,;-5.82,-.45,;-6.59,-1.79,;-8.15,-1.83,;-8.9,-.45,;-8.13,.88,;-8.92,-3.17,;-9.69,-4.5,;-10.26,-2.4,;-7.59,-3.94,;-3,2.59,;4.27,.71,;5.59,-.1,;5.23,-1.59,;6.23,-2.76,;6.23,-4.3,;7.56,-5.07,;8.9,-4.3,;10.23,-5.07,;8.9,-2.76,;7.56,-1.99,)|
Structure:
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