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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM372260
Substrate
n/a
Meas. Tech.
Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity
EC50
23.0±n/a nM
Citation
 Lindsley, CW; Conn, PJ; Engers, DW; Bollinger, S; Tarr, JC; Spearing, P; Engers, JL; Long, M; Bridges, TM Positive allosteric modulators of the muscarinic acetylcholine receptor M4 US Patent  US10239887 Publication Date 3/26/2019 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM372260
Synonyms:
2-[4-[[(3,4-Dimethylpyrimido[4',5':4,5]thieno[2,3-c]pyridazin-8-yl)amino]methyl]phenyl]propan-2-ol | US10239887, Cpd. No. 76
Type:
Small organic molecule
Emp. Form.:
C20H21N5OS
Mol. Mass.:
379.479
SMILES:
Cc1nnc2sc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c2c1C
Structure:
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