Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375092
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
3.00±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375092
Synonyms:
(1S,2S)-2-(5-{(R)-4-[2,6-Dimethyl-4-(2-methyl-2H-tetrazol-5-yl)-phenyl]-indan-1-ylamino}-pyrazin-2-yl)-cyclopropanecarboxylic acid | US10253004, Example 6
Type:
Small organic molecule
Emp. Form.:
C27H27N7O2
Mol. Mass.:
481.549
SMILES:
Cc1cc(cc(C)c1-c1cccc2[C@@H](CCc12)Nc1cnc(cn1)[C@H]1C[C@@H]1C(O)=O)-c1nnn(C)n1 |r,wU:24.27,13.19,wD:26.31,(-3.21,.04,;-4.71,-.28,;-5.74,.87,;-7.25,.55,;-7.73,-.92,;-6.7,-2.06,;-7.17,-3.53,;-5.19,-1.74,;-4.16,-2.89,;-4.64,-4.35,;-3.6,-5.5,;-2.1,-5.18,;-1.62,-3.71,;-.22,-3.09,;-.38,-1.55,;-1.88,-1.23,;-2.65,-2.57,;1.1,-3.86,;2.44,-3.09,;2.44,-1.55,;3.77,-.78,;5.1,-1.55,;5.1,-3.09,;3.77,-3.86,;6.44,-.78,;7.77,-.01,;7.77,-1.55,;9.11,-.78,;10.44,-1.55,;9.11,.76,;-8.28,1.69,;-9.81,1.53,;-10.44,2.94,;-9.29,3.97,;-9.46,5.5,;-7.96,3.2,)|
Structure:
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