Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375102
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
77.0±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375102
Synonyms:
US10253004, Example 16
Type:
Small organic molecule
Emp. Form.:
C23H18F3N3O2
Mol. Mass.:
425.4031
SMILES:
OC(=O)[C@H]1C[C@@H]1c1cnc(N[C@@H]2CCc3c2c(F)ccc3-c2c(F)cccc2F)cn1 |r,wU:5.6,11.11,wD:3.2,(11.66,-1.36,;10.33,-.59,;10.33,.95,;8.99,-1.36,;8.99,.18,;7.66,-.59,;6.32,-1.36,;6.32,-2.9,;4.99,-3.67,;3.66,-2.9,;2.32,-3.67,;1,-2.9,;.84,-1.37,;-.66,-1.05,;-1.43,-2.38,;-.4,-3.53,;-.88,-4.99,;.15,-6.13,;-2.38,-5.31,;-3.42,-4.17,;-2.94,-2.7,;-3.97,-1.56,;-5.48,-1.88,;-5.95,-3.34,;-6.51,-.73,;-6.03,.73,;-4.52,1.05,;-3.49,-.09,;-1.99,.23,;3.66,-1.36,;4.99,-.59,)|
Structure:
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