Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375112
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
367±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375112
Synonyms:
US10253004, Example 26
Type:
Small organic molecule
Emp. Form.:
C27H23FN4O2
Mol. Mass.:
454.4955
SMILES:
OC(=O)[C@H]1C[C@@H]1c1cnc(N[C@@H]2CCc3c2c(F)ccc3-c2ccccc2C2(CC2)C#N)cn1 |r|
Structure:
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