Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375120
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
9.00±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375120
Synonyms:
US10253004, Example 34
Type:
Small organic molecule
Emp. Form.:
C32H30FN3O2
Mol. Mass.:
507.5979
SMILES:
Cc1cc(Cc2ccccc2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cnc(cn1)[C@H]1C[C@@H]1C(O)=O |r,wU:32.36,21.28,wD:34.40,(-5.95,-3.34,;-5.48,-1.88,;-6.51,-.73,;-6.03,.73,;-7.06,1.88,;-6.59,3.34,;-5.08,3.66,;-4.6,5.13,;-5.63,6.27,;-7.14,5.95,;-7.62,4.49,;-4.52,1.05,;-3.49,-.09,;-1.99,.23,;-3.97,-1.56,;-2.94,-2.7,;-3.42,-4.17,;-2.38,-5.31,;-.88,-4.99,;.15,-6.13,;-.4,-3.53,;1,-2.9,;.84,-1.37,;-.66,-1.05,;-1.43,-2.38,;2.32,-3.67,;3.66,-2.9,;3.66,-1.36,;4.99,-.59,;6.32,-1.36,;6.32,-2.9,;4.99,-3.67,;7.66,-.59,;8.99,.18,;8.99,-1.36,;10.33,-.59,;11.66,-1.36,;10.33,.95,)|
Structure:
Search PDB for entries with ligand similarity: