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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM375227
Substrate
n/a
Meas. Tech.
Binding to Melatonin MT3 Binding Sites
IC50
130±n/a nM
Citation
 Castro-Palomino Laria, JC; Camacho Gómez, JA; Mendoza Lizaldez, A Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors US Patent  US10253017 Publication Date 4/9/2019 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM375227
Synonyms:
3-chloro-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-2-amine | US10253017, Example 21
Type:
Small organic molecule
Emp. Form.:
C15H11ClN4
Mol. Mass.:
282.728
SMILES:
Nc1cc(Cl)c(-c2ccncc2)c(n1)-c1cccnc1
Structure:
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