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Target
Adenosine receptor A2b
Ligand
BDBM375234
Substrate
n/a
Meas. Tech.
Adenosine A2B Receptor Subtype Competition Radioligand Binding Assay
Ki
24.0±n/a nM
Citation
 Castro-Palomino Laria, JC; Camacho Gómez, JA; Mendoza Lizaldez, A Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors US Patent  US10253017 Publication Date 4/9/2019 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM375234
Synonyms:
3-chloro-5-(3-fluoropyridin-4-yl)-6-(6-methoxypyridin-3-yl)pyridin-2-amine | US10253017, Example 36
Type:
Small organic molecule
Emp. Form.:
C16H12ClFN4O
Mol. Mass.:
330.744
SMILES:
COc1ccc(cn1)-c1nc(N)cc(Cl)c1-c1ccnc(F)c1
Structure:
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