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Target
Tyrosine-protein kinase BTK
Ligand
BDBM165582
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
0.140±n/a nM
Citation
 Liu, Q; Watterson, SH; Ahmad, S Indole carboxamide compounds US Patent  US9920031 Publication Date 3/20/2018 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM165582
Synonyms:
US10604504, Example 193 | US11623921, Example 193 | US9688629, 193 | US9802915, Example 193 | US9920031, Example 193
Type:
Small organic molecule
Emp. Form.:
C22H20FN3O2
Mol. Mass.:
377.4115
SMILES:
Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCc34)C(=O)C=C)c2c1C)C(N)=O |(-5.51,2.3,;-3.97,2.3,;-3.06,3.54,;-1.6,3.07,;-.26,3.84,;1.07,3.07,;1.07,1.53,;2.4,.76,;-.26,.76,;-.26,-.78,;-1.6,-1.55,;-1.6,-3.09,;-.26,-3.86,;1.07,-3.09,;2.53,-3.57,;3.44,-2.32,;2.53,-1.08,;1.07,-1.55,;2.93,-5.06,;1.84,-6.15,;4.42,-5.46,;5.51,-4.37,;-1.6,1.53,;-3.06,1.05,;-3.52,-.28,;-.26,5.38,;1.07,6.15,;-1.6,6.15,)|
Structure:
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