Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM376775
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<100±n/a nM
Citation
Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as pim kinase inhibitors US Patent US9920032 Publication Date 3/20/2018
More Info.:
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
Inhibitor
Name:
BDBM376775
Synonyms:
N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)-5-fluoroquinoline-8-carboxamide | US10450296, Example 106 | US11053215, Example 106 | US9920032, Example 106
Type:
Small organic molecule
Emp. Form.:
C29H34FN5O2
Mol. Mass.:
503.611
SMILES:
C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1C2CCCC1COC2 |r,THB:24:28:30.32.31:34.36.35|