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Target
Tyrosine-protein kinase BTK
Ligand
BDBM378879
Substrate
n/a
Meas. Tech.
Detection of In Vitro Inhibition Activity (Enzymatic Activity)
IC50
343±n/a nM
Citation
 Liu, J; Liu, Q; Li, X; Wang, A; Wu, H; Chen, C; Wang, W; Hu, C; Zhao, Z; Wu, J; Liu, J; Yu, K; Wang, W; Wang, L; Wang, B Inhibitor of FLT3 kinase and use thereof US Patent  US10266535 Publication Date 4/23/2019 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM378879
Synonyms:
US10266535, Compound 78
Type:
Small organic molecule
Emp. Form.:
C24H26N6O3S
Mol. Mass.:
478.567
SMILES:
CS(=O)(=O)NC1CC[C@@H](CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:8.11,(3.79,-8.04,;2.31,-7.64,;1.91,-9.13,;2.7,-6.15,;.82,-7.24,;.42,-5.75,;1.51,-4.66,;1.11,-3.18,;-.38,-2.78,;-1.47,-3.87,;-1.07,-5.36,;-1.15,-1.45,;-.24,-.2,;-1.15,1.05,;-.38,2.38,;1.11,2.78,;1.51,4.27,;.42,5.36,;.82,6.84,;2.31,7.24,;3.39,6.15,;4.88,6.55,;5.28,8.04,;4.19,9.13,;2.7,8.73,;-1.07,4.96,;-1.47,3.47,;-2.61,.57,;-3.95,1.34,;-3.95,2.88,;-5.28,.57,;-5.28,-.97,;-3.95,-1.74,;-2.61,-.97,)|
Structure:
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