Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM261736
Substrate
n/a
Meas. Tech.
M1 PAM Assay
EC50
41.0±n/a nM
Citation
 Groebke Zbinden, K; Pinard, E; Ryckmans, T Flouro-naphthyl derivatives US Patent  US9708302 Publication Date 7/18/2017 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM261736
Synonyms:
1-fluoro-N- ((1SR,2RS)-2- hydroxy-2- methylcyclohexyl)- 4-((6-(1-methyl-1H- pyrazol-4-yl)pyridin- 3-yl)methyl)-2- naphthamide | US9708302, 22
Type:
Small organic molecule
Emp. Form.:
C28H29FN4O2
Mol. Mass.:
472.5539
SMILES:
Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@]3(C)O)c(F)c3ccccc23)cn1 |r|
Structure:
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