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Target
Proto-oncogene tyrosine-protein kinase Src [1-530]
Ligand
BDBM50086445
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assays
IC50
7.00±n/a nM
Citation
 Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent  US10266537 Publication Date 4/23/2019 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [1-530]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src (aa 1-530) | SRC | SRC1 | SRC_HUMAN | c-Src (aa 1-530)
Type:
n/a
Mol. Mass.:
59200.93
Organism:
Homo sapiens (Human)
Description:
P12931[1-530]
Residue:
530
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY
  
Inhibitor
Name:
BDBM50086445
Synonyms:
CHEMBL3426229 | US10266537, Compound 21
Type:
Small organic molecule
Emp. Form.:
C32H33F3N8O2
Mol. Mass.:
618.652
SMILES:
CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nn([C@H]4CCOC4)c4ncnc(N)c34)cc2C(F)(F)F)CC1 |r|
Structure:
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