Reaction Details Report a problem with these data
Target
Proto-oncogene tyrosine-protein kinase Src [1-530]
Ligand
BDBM378888
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assays
IC50
12.0±n/a nM
Citation
 Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent  US10266537 Publication Date 4/23/2019 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [1-530]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src (aa 1-530) | SRC | SRC1 | SRC_HUMAN | c-Src (aa 1-530)
Type:
n/a
Mol. Mass.:
59200.93
Organism:
Homo sapiens (Human)
Description:
P12931[1-530]
Residue:
530
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY
  
Inhibitor
Name:
BDBM378888
Synonyms:
Preparation of 3-(4-amino-1-(piperidin-4-yl)-1H-pyrazolo [3, 4-d] pyrimidin-3-yl) ethynyl)-4-methyl-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) phenyl) benzamide | US10266537, Compound 120
Type:
Small organic molecule
Emp. Form.:
C33H35F3N8O3
Mol. Mass.:
648.678
SMILES:
CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nn(C(=O)OC(C)(C)C)c4ncnc(N)c34)cc2C(F)(F)F)CC1
Structure:
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