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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM24929
Substrate
Cdc25C Substrate Peptide
Meas. Tech.
Plk in Vitro Assay
pH
7.2±n/a
Temperature
303.15±n/a K
IC50
1170±n/a nM
Citation
 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett 18:5186-9 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM24929
Synonyms:
2-amino-isoxazolopyridine, 5 | 3-(4-methylphenyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine
Type:
Small organic molecule
Emp. Form.:
C21H19N3O
Mol. Mass.:
329.3951
SMILES:
C[C@H](Nc1cc2c(noc2cn1)-c1ccc(C)cc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Cdc25C Substrate Peptide
Synonyms:
5-carboxamido-fluorescein (5FAM) labeled peptide
Type:
Fluorophore tagged peptide
Mol. Mass.:
2066.83
Organism:
n/a
Description:
n/a
Residue:
18
Sequence:
FAMRALMEASFADQARNH