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Target
Protein-tyrosine kinase 6
Ligand
BDBM24941
Substrate
BDBM10852
Meas. Tech.
Kinase Selectivity Assay
IC50
267000±n/a nM
Citation
 Uckun, FM; Dibirdik, I; Qazi, S; Vassilev, A; Ma, H; Mao, C; Benyumov, A; Emami, KH Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK). Bioorg Med Chem 15:800-14 (2007) [PubMed]  Article 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM24941
Synonyms:
(2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methylidene}-3-oxobutanenitrile | CHEMBL228043 | LFM-A13 | Thr1 inhibitor, 2 | alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide
Type:
Small organic molecule
Emp. Form.:
C11H8Br2N2O2
Mol. Mass.:
360.001
SMILES:
CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br
Structure:
Search PDB for entries with ligand similarity:
Substrate