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Target
NAD(P)H dehydrogenase [quinone] 1
Ligand
BDBM381867
Substrate
n/a
Meas. Tech.
BEAS-2B NQO1 MTT Assay
EC50
5500±n/a nM
Citation
 Kerns, JK; Callahan, JF; Yan, H; Heightman, TD; Boehm, JC; Woolford, AJ NRF2 regulators US Patent  US10272095 Publication Date 4/30/2019 
Target
Name:
NAD(P)H dehydrogenase [quinone] 1
Synonyms:
Azoreductase | DIA4 | DT-diaphorase | Menadione reductase | NAD(P)H:quinone oxidoreductase 1 | NMOR1 | NQO1 | NQO1_HUMAN | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:
Homodimer
Mol. Mass.:
30874.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
  
Inhibitor
Name:
BDBM381867
Synonyms:
3-(1,4-Dimethyl-1H-1,2,3-benzotriazol-5-yl)-3-[1-(2-phenylpropanoyl)-1H,2H,3H,3aH,4H,8bH-indeno[1,2-b]pyrrol-7-yl]propanoic Acid | US10272095, Example 8 | US10272095, Example 9
Type:
Small organic molecule
Emp. Form.:
C31H32N4O3
Mol. Mass.:
508.6108
SMILES:
CC(C(=O)N1CCC2Cc3ccc(cc3C12)C(CC(O)=O)c1ccc2n(C)nnc2c1C)c1ccccc1
Structure:
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