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Target
NAD(P)H dehydrogenase [quinone] 1
Ligand
BDBM381874
Substrate
n/a
Meas. Tech.
BEAS-2B NQO1 MTT Assay
EC50
550±n/a nM
Citation
 Kerns, JK; Callahan, JF; Yan, H; Heightman, TD; Boehm, JC; Woolford, AJ NRF2 regulators US Patent  US10272095 Publication Date 4/30/2019 
Target
Name:
NAD(P)H dehydrogenase [quinone] 1
Synonyms:
Azoreductase | DIA4 | DT-diaphorase | Menadione reductase | NAD(P)H:quinone oxidoreductase 1 | NMOR1 | NQO1 | NQO1_HUMAN | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:
Homodimer
Mol. Mass.:
30874.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
  
Inhibitor
Name:
BDBM381874
Synonyms:
3-(3-(2,2-Dimethyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)-2,3-dihydro-1H-inden-5-yl)-3-(4-fluoro-2-methyl phenyl)propanoic Acid, Formic Acid Salt | US10272095, Example 60
Type:
Small organic molecule
Emp. Form.:
C29H31FN2O3
Mol. Mass.:
474.5664
SMILES:
Cc1cc(F)ccc1C(CC(O)=O)c1ccc2CCC(N3Cc4cccnc4OC(C)(C)C3)c2c1
Structure:
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