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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM12915
Substrate
Biotinylated PLKtide
Meas. Tech.
PLK Kinase Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
6100±n/a nM
Km
200±n/a nM
Citation
 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity. Biochemistry 46:9551-63 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM12915
Synonyms:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one | CHEMBL98350 | LY294002 | US10308662, Compound LY294002 | US9505780, LY294002
Type:
Small organic molecule
Emp. Form.:
C19H17NO3
Mol. Mass.:
307.3432
SMILES:
O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated PLKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1447.52
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
EVIEASFAEQEAK