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Target
Proto-oncogene Wnt-1
Ligand
BDBM385240
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
472±n/a nM
Citation
 KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent  US10287267 Publication Date 5/14/2019 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM385240
Synonyms:
US10287267, Compound 707 | US10508099, Compound 707 | US10556885, Compound 707 | US11174244, Compound 707 | US11673881, Compound 707
Type:
Small organic molecule
Emp. Form.:
C21H24N4OS
Mol. Mass.:
380.506
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncs1 |r,wU:3.2,wD:6.9,(9.19,1.15,;7.85,1.93,;7.85,3.47,;6.52,1.15,;6.52,-.38,;5.19,-1.15,;3.85,-.38,;3.85,1.15,;5.19,1.93,;2.52,-1.15,;2.52,-2.69,;1.18,-.38,;-.15,-1.15,;-1.48,-.38,;-2.82,-1.15,;-4.15,-.38,;-5.48,-1.15,;-5.48,-2.69,;-4.15,-3.47,;-2.82,-2.69,;-1.48,-3.47,;-.15,-2.69,;-6.82,-.38,;-8.28,-.86,;-9.19,.38,;-8.28,1.63,;-6.82,1.15,)|
Structure:
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