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Target
Prolyl hydroxylase EGLN2
Ligand
BDBM385680
Substrate
n/a
Meas. Tech.
PHD1 Enzyme Assay
IC50
29.0±n/a nM
Citation
 Ahmed, S; Barker, G; Canning, H; Davenport, R; Harrison, D; Jenkins, K; Livermore, D; Wright, S; Kinsella, N Compounds US Patent  US10287286 Publication Date 5/14/2019 
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
  
Inhibitor
Name:
BDBM385680
Synonyms:
4-(5-{[3- (dimethylamino) propyl]amino}- [1,2,4]triazolo[1,5- a]pyrimidin-7- yl)benzonitrile | US10287286, Example 88
Type:
Small organic molecule
Emp. Form.:
C17H19N7
Mol. Mass.:
321.3797
SMILES:
CN(C)CCCNc1cc(-c2ccc(cc2)C#N)n2ncnc2n1
Structure:
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