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Target
Ribosomal protein S6 kinase beta-1 [T412E]
Ligand
BDBM386005
Substrate
n/a
Meas. Tech.
P70S6K Enzyme Assay
IC50
750±n/a nM
Citation
 Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent  US10287300 Publication Date 5/14/2019 
Target
Name:
Ribosomal protein S6 kinase beta-1 [T412E]
Synonyms:
KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59166.89
Organism:
Homo sapiens (Human)
Description:
P23443[T412E]
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM386005
Synonyms:
US10287300, Compound A12 | [2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yl)-piperazin-1-yl]-2-(3-fluoro-4-trifluoromethylphenyl)-ethyl]-dimethylamine
Type:
Small organic molecule
Emp. Form.:
C21H26F4N6O
Mol. Mass.:
454.4644
SMILES:
CN(C)CC(N1CCN(CC1)c1ncnc2NCCOc12)c1ccc(c(F)c1)C(F)(F)F
Structure:
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