Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM387140
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
117±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists US Patent  US9938276 Publication Date 4/10/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM387140
Synonyms:
2-((3aS, 7aS)-6-(3-(1H-pyrazol-1- yl)pyrazine-2-carbonyl)octahydro- 1H-pyrrolo[2,3-c]pyridin-1- yl)isonicotinonitrile | US9938276, D6
Type:
Small organic molecule
Emp. Form.:
C21H20N8O
Mol. Mass.:
400.4365
SMILES:
O=C(N1CC[C@H]2CCN([C@H]2C1)c1cc(ccn1)C#N)c1nccnc1-n1cccn1
Structure:
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