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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM387784
Substrate
n/a
Meas. Tech.
Determination of Allosteric Potency EC50 Values for Muscarinic M1 Receptor
EC50
1492±n/a nM
Citation
 Nirogi, R; Shinde, AK; Mohammed, AR; Subramanian, R; Benade, VS; Bhyrapuneni, G; Jasti, V Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators US Patent  US10294217 Publication Date 5/21/2019 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM387784
Synonyms:
US10294217, Example 4
Type:
Small organic molecule
Emp. Form.:
C24H25FN4O2
Mol. Mass.:
420.4793
SMILES:
Cn1nc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3c(F)cccc23)c2ccccc12 |r|
Structure:
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