Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM387812
Substrate
n/a
Meas. Tech.
Determination of Allosteric Potency EC50 Values for Muscarinic M1 Receptor
EC50
1485±n/a nM
Citation
 Nirogi, R; Shinde, AK; Mohammed, AR; Subramanian, R; Benade, VS; Bhyrapuneni, G; Jasti, V Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators US Patent  US10294217 Publication Date 5/21/2019 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM387812
Synonyms:
US10294217, Example 39
Type:
Small organic molecule
Emp. Form.:
C22H22F3N3O2
Mol. Mass.:
417.4242
SMILES:
COc1ccc(Cn2cc(C(=O)NC3CCNCC3F)c3c(F)ccc(F)c23)cc1
Structure:
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