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Target
Proteasome subunit beta type-5
Ligand
BDBM388331
Substrate
n/a
Meas. Tech.
Determination of Beta5 Activity
IC50
2750±n/a nM
Citation
 Klein, M; Schadt, O; Haselmayer, P; Busch, M Substituted boronic acids and boronate esters as immunoproteasome inhibitors US Patent  US10294246 Publication Date 5/21/2019 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM388331
Synonyms:
US10294246, Compound No. 28
Type:
Small organic molecule
Emp. Form.:
C19H17BF3NO5
Mol. Mass.:
407.148
SMILES:
OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccccc1OC(F)(F)F |r|
Structure:
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