Reaction Details Report a problem with these data
Target
Sodium/glucose cotransporter 1
Ligand
BDBM254941
Substrate
n/a
Meas. Tech.
SGLT2 and SGLT1 Inhibition
IC50
251±n/a nM
Citation
 Zhao, G; Wang, Y; Liu, B; Xie, Y; Liu, Y; Liu, P; Wu, J; Hou, J; Wei, W; Du, W; Xu, W; Tang, L; Zou, M Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof US Patent  US10294259 Publication Date 5/21/2019 
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
  
Inhibitor
Name:
BDBM254941
Synonyms:
US10294259, Compound Table 3.2 | US9505734, I-D1-6
Type:
Small organic molecule
Emp. Form.:
C21H25ClO5
Mol. Mass.:
392.873
SMILES:
CCOc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Structure:
Search PDB for entries with ligand similarity: