Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM392683
Substrate
n/a
Meas. Tech.
Test for Evaluating Human MC Receptor Activation, Using Cells Expressing Human MC4, MC1, or MC3 Receptor
EC50
2900±n/a nM
Citation
 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Piperazine derivative US Patent  US10301286 Publication Date 5/28/2019 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM392683
Synonyms:
US10301286, Example 69
Type:
Small organic molecule
Emp. Form.:
C30H38ClF2N3O4
Mol. Mass.:
578.09
SMILES:
COc1ccc(C[C@H](N2CCN([C@@H](C)C2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(Cl)cc2F)C(C)(C)C)C(O)=O)c(F)c1 |r|
Structure:
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