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Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM392959
Substrate
n/a
Meas. Tech.
RIPK3 HTRF Kinase Assay
IC50
<30±n/a nM
Citation
 Hart, AC; Pitts, WJ; Mastalerz, H; Guo, J; Brown, GD Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors US Patent  US10301306 Publication Date 5/28/2019 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM392959
Synonyms:
1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrolo[3,2-c]pyridin-4(5H)-one | US10301306, Example 157
Type:
Small organic molecule
Emp. Form.:
C26H16F5N3O
Mol. Mass.:
481.4168
SMILES:
Fc1ccc(cc1)-c1c(-c2ccncc2)n(Cc2ccc(cc2F)C(F)(F)F)c2cc[nH]c(=O)c12
Structure:
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