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Target
Mitogen-activated protein kinase 1
Ligand
BDBM318081
Substrate
n/a
Meas. Tech.
Inhibition Assays of ERK
IC50
<50±n/a nM
Citation
 Li, L; Wu, T; Feng, J; Ren, P; Liu, Y Inhibitors of ERK and methods of use US Patent  US10301317 Publication Date 5/28/2019 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM318081
Synonyms:
US10301317, Example 37 | US9624228, Example 37
Type:
Small organic molecule
Emp. Form.:
C21H16ClFN6O2
Mol. Mass.:
438.842
SMILES:
COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12
Structure:
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