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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM457
Substrate
n/a
Meas. Tech.
Protease Inhibition Assay
IC50
1.7±n/a nM
Citation
Boyer, FE; Vara Prasad, JV; Domagala, JM; Ellsworth, EL; Gajda, C; Hagen, SE; Markoski, LJ; Tait, BD; Lunney, EA; Palovsky, A; Ferguson, D; Graham, N; Holler, T; Hupe, D; Nouhan, C; Tummino, PJ; Urumov, A; Zeikus, E; Zeikus, G; Gracheck, SJ; Sanders, JM; VanderRoest, S; Brodfuehrer, J; Iyer, K; Sinz, M; Gulnik, SV 5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease. J Med Chem 43:843-58 (2000) [PubMed] Article
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM457
Synonyms:
3-({2-tert-butyl-4-[(ethylsulfamoyl)amino]-5-methylphenyl}sulfanyl)-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-(propan-2-yl)-5,6-dihydro-2H-pyran-2-one | CHEMBL172271 | Dihydropyran-2-one deriv. 62
Type:
Small organic molecule
Emp. Form.:
C29H40N2O6S2
Mol. Mass.:
576.768
SMILES:
CCNS(=O)(=O)Nc1cc(c(SC2C(=O)CC(CCc3ccc(O)cc3)(OC2=O)C(C)C)cc1C)C(C)(C)C